Lu Chen

This study shows that reduced Satb2 gene dosage in cortical projection neurons leads to chromatin and circuit defects, causing cognitive and sensory impairments in a mouse model of SATB2-associated syndrome.

This study identifies a RA-mediated retrograde signaling pathway where postsynaptic BDNF synthesis during synaptic inactivity drives presynaptic homeostatic compensation.

This study identifies RAR-mediated homeostatic plasticity as a mechanism driving spinal disinhibition and mechanical allodynia after peripheral nerve injury.