Grégory Scherrer

The paper identifies a specific neural circuit between the ACC and dlPAG that facilitates the affective component of pain, showing its role in aversive behaviors beyond pain.

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

The paper uses cryo-EM to analyze endogenous mGluR2-containing receptor assemblies in mouse brain, revealing distinct structural states and complexes not previously observed in recombinant systems.

This study shows that motor cortical stimulation induces long-term pain relief through opioid and NMDA-receptor-dependent neural plasticity in the rostral ventromedial medulla.

This study identifies cerebellar and pontine brain regions involved in human placebo analgesia, linking findings from animal models to human neuroimaging data.

This study creates a human assembloid model of the ascending somatosensory pathway using pluripotent stem cells and demonstrates its functional connectivity and response to pain-related stimuli.

This study identifies IL-10's role in upregulating delta opioid receptor to prevent pain relapse during remission.

This study maps the development of sensory and sympathetic innervation in the kidney, identifying key nerve types and their origins.

The paper identifies distinct transcriptional responses in microglia during opioid exposure and neuropathic pain, highlighting injury-specific mechanisms and the absence of opioid-induced transcriptional changes.

The paper uses graph theory to analyze the structural pain network, revealing it is assortative and vulnerable to attacks on hub nodes.

The paper maps opioid receptor expression across brainstem circuits and identifies functional implications in respiratory and sensory pathways.

This study identifies RAR-mediated homeostatic plasticity as a mechanism driving spinal disinhibition and mechanical allodynia after peripheral nerve injury.

This study investigates how opioids modulate glutamate transmission in thalamo-cortico-striatal circuits in mice, revealing distinct effects of mu- and delta-opioid receptors on neural activity.

This paper develops light-inducible methods to activate TrkA signaling without NGF, enabling precise spatial and temporal control of neuronal signaling pathways.