Author

Yuvaraj Bhoobalan-Chitty

University of CopenhagenORCID 0000-0002-8104-7657Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:genome assembly· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Marianne De PaepeiD· 2 shared Mathieu StoufiD· 2 shared Anton Lukas Ipsen WolffiD· 1 shared David Mayo-MuñoziD· 1 shared François LecointeiD· 1 shared Frédéric BonhommeiD· 1 shared Karen Baadsgaard· 1 shared Luis Ramirez-ChamorroiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

Marianne De PaepeORCID

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3 papers

Recent·Most cited

A Pair of DNA Glucosyltransferases Elevate Counter-defense in Bacteriophage T4

Luis Ramirez-Chamorro, Frédéric Bonhomme, Anton Lukas Ipsen Wolff, Mathieu Stouf, François Lecointe, Marcel Hollenstein, Mart Krupovìč, Marianne De Paepe, Yuvaraj Bhoobalan-Chitty

This study shows that bacteriophage T4 uses two glucosyltransferases to modify its DNA, helping it evade bacterial defense systems, with redundancy providing an evolutionary advantage.

Nucleic Acids Research · May 14, 2026Peer-reviewedMicrobiology

Genetic manipulation of Bacteriophage T4 utilizing the CRISPR-Cas13b system

Yuvaraj Bhoobalan-Chitty, Mathieu Stouf, Marianne De Paepe

This paper describes a CRISPR-Cas13b-based method to edit the T4 bacteriophage genome, enabling gene deletions, mutations, and fluorescent protein insertion for studying phage biology.

Frontiers in Genome Editing · Dec 19, 2024Peer-reviewedSynthetic Biology

Multilayered interaction between CRISPR-Cas subtype I-A and adjacently encoded Acrs of virus SIRV2

Yuvaraj Bhoobalan-Chitty, Nicodemus Dwiputra, David Mayo-Muñoz, Karen Baadsgaard, Mette Rehtse Kvistrup Skafte Detlefsen, Xu Peng

The paper investigates the interaction between CRISPR-Cas subtype I-A and two adjacent Acrs in SIRV2, showing how they modulate viral infectivity and host immunity.

bioRxiv · Apr 2, 2024 · PreprintMicrobiology