David Mayo-Muñoz

This study compares CRISPR-Cas systems for RNA knockdown in rat sensory neurons, finding hfCas13d provides robust gene silencing with minimal toxicity.

This paper identifies viral single-guide RNAs (vsgRNAs) that subvert bacterial CRISPR-Cas9 immunity by sequestering Cas9 and redirecting its activity, and shows they can enable genome editing in mammalian cells.

The paper investigates the interaction between CRISPR-Cas subtype I-A and two adjacent Acrs in SIRV2, showing how they modulate viral infectivity and host immunity.

CRISPRCasTyper is a tool that identifies and classifies CRISPR-Cas loci in prokaryotic sequences using machine learning, achieving high accuracy in subtyping and handling fragmented data.