Frédéric Bonhomme

This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.

This study shows HRV16 impairs macrophage cytokine secretion by disrupting NF-κB nuclear translocation and intracellular cytokine trafficking, with associated epigenetic changes.

This study shows that bacteriophage T4 uses two glucosyltransferases to modify its DNA, helping it evade bacterial defense systems, with redundancy providing an evolutionary advantage.

This study shows UHRF1 has non-canonical roles beyond DNMT1 activation in maintaining DNA methylation homeostasis in cancer cells.

This study identifies DAXX's role in maintaining heterochromatin structure in ESCs by recruiting PML and SETDB1, and shows its importance for genome integrity and pluripotency.

The paper identifies new regulators of germline genes and 2-cell like cell state through a genome-wide CRISPR knock-out screen in mouse ES cells.

The paper characterizes oxidized 5mC forms in Plasmodium falciparum and shows DNMT2 and oxygen levels influence their epigenetic landscape.

This paper identifies three genes in cyanophage S-2L that enable the synthesis of 2-aminoadenine in bacterial DNA, demonstrating their function in a synthetic system.