Yuanchao Xue

The paper maps circRNA-target RNA interactions using RIC-seq, identifies translational repression by P-bodies, and highlights disease relevance of interaction sites.

This study identifies low-frequency variants in FKBP5 and FOLH1 associated with high myopia in Han Chinese and European populations through whole-exome sequencing and functional experiments.

This study identifies YTHDC1 as a critical regulator of muscle stem cell activation and proliferation by modulating mRNA splicing and nuclear export during regeneration.

CRIC-seq identifies PTBP1-mediated RNA loops that regulate splicing by position-dependent mechanisms, revealing how disruptions in these loops contribute to cancer-related splicing defects.

This study converts astrocytes into functional neurons to reverse Parkinson's disease in mice by suppressing PTB, restoring dopamine levels and nigrostriatal pathways.