Ruibao Su

N-acetyltransferase 10-mediated mRNA N4-acetylation is Essential for the Translational Regulation During Oocyte Meiotic Maturation in Mice

This study develops ac4C LACE-seq to profile mRNA N4-acetylation in mouse oocytes and shows NAT10 is essential for ac4C modification, which enhances translation efficiency during meiotic maturation.

Nuclear m6A Reader YTHDC1 Promotes Muscle Stem Cell Activation/Proliferation by Regulating mRNA Splicing and Nuclear Export

This study identifies YTHDC1 as a critical regulator of muscle stem cell activation and proliferation by modulating mRNA splicing and nuclear export during regeneration.

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

This study shows that SRSF10 regulates alternative splicing in progenitor spermatogonia, essential for their expansion and spermatogenesis.

SRSF2 is required for mRNA splicing and spermatogenesis

This study shows SRSF2 is essential for mRNA splicing and spermatogenesis, with its deletion causing infertility and disrupting key developmental processes.

CRIC-seq reveals positional rule of PTBP1-mediated long-range RNA looping in splicing regulation

CRIC-seq identifies PTBP1-mediated RNA loops that regulate splicing by position-dependent mechanisms, revealing how disruptions in these loops contribute to cancer-related splicing defects.