Xiang‐Dong Fu

The paper shows that ecDNA interactomes are shaped by nascent RNA, with PVT1 and MYC ecDNA using noncoding RNA for trans-activation, while EGFR ecDNA is less effective due to efficient splicing.

The paper evaluates eight R-loop mapping technologies, identifies biases and artifacts, and classifies R-loops into two distinct types based on RPA binding patterns.

The paper shows that active retrotransposons produce siRNAs that maintain pericentromeric heterochromatin, ensuring stable genetic inheritance in Drosophila cells.

The paper maps and characterizes RNA elements recognized by human RNA binding proteins in K562 and HepG2 cells, expanding the catalog of functional elements in the human genome.

This study converts astrocytes into functional neurons to reverse Parkinson's disease in mice by suppressing PTB, restoring dopamine levels and nigrostriatal pathways.

The paper analyzes eCLIP data for 150 RBPs in K562 and HepG2 cells, revealing binding modalities, RBP functions, and novel RNA processing mechanisms.