Author

Hendrika A. Segeren

Royal Netherlands Academy of Arts and SciencesORCID 0000-0002-8115-6482Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bart WestendorpiD· 2 shared Bram ThijsseniD· 1 shared Elsbeth A. van LiereiD· 1 shared Frank M. RiemersiD· 1 shared Kathryn A. WierengaiD· 1 shared Lodewyk F.A. WesselsiD· 1 shared Qingwu LiuiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

Bart WestendorpORCID

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2 papers

Recent·Most cited

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance.

Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp

The paper identifies FOXM1 expression levels as a factor in replication stress tolerance in oncogenic RAS-expressing cells using single-cell RNA sequencing and drug combination experiments.

Molecular Oncology · Feb 26, 2025Peer-reviewedCancer Biology

Inferring single-cell protein levels and cell cycle behavior in heterogeneous cell populations

Bram Thijssen, Hendrika A. Segeren, Qingwu Liu, Lodewyk F.A. Wessels, Bart Westendorp

The paper introduces scMeMo, a mechanistic modeling framework that infers unobserved variables in single cells using diverse measurements, demonstrating its ability to predict protein levels and cell cycle behavior from limited data.

bioRxiv · Aug 24, 2023 · PreprintSystems Biology