Bram Thijssen

ESGI provides a flexible framework for demultiplexing and processing single-cell sequencing data with arbitrary barcode architectures, supporting complex and emerging experimental designs.

The paper shows that mitochondrial damage can induce therapy-induced senescence in GBM cells through a ROS-cGAS-STING-SASP cascade, outperforming single or dual pathway inhibitors.

The paper introduces scMeMo, a mechanistic modeling framework that infers unobserved variables in single cells using diverse measurements, demonstrating its ability to predict protein levels and cell cycle behavior from limited data.

This paper develops feedback-ISA (f-ISA) to model feedback mechanisms in signaling pathways, showing it can explain phosphorylation levels in MAPK and AKT pathways across breast cancer cell lines and conditions.