Bart Westendorp

The paper develops an in vitro MASH model to study metabolite crosstalk between Kupffer cells and hepatocytes, identifying itaconate as a key mediator of liver disease progression.

This study shows E2F3 amplification in bladder cancer cells leads to premature mitosis, which can be targeted by G2/M checkpoint inhibitors.

This study shows Salmonella uses 2,3-sialylated MUC1 on colonocytes for apical invasion, identified through glycan analysis and ex vivo models.

The paper identifies FOXM1 expression levels as a factor in replication stress tolerance in oncogenic RAS-expressing cells using single-cell RNA sequencing and drug combination experiments.

The paper introduces scMeMo, a mechanistic modeling framework that infers unobserved variables in single cells using diverse measurements, demonstrating its ability to predict protein levels and cell cycle behavior from limited data.