PFM: perturbed flow matching for structure-based drug design
Yankai Yu, Guikun Xu, Zhuyang Xie, Yi Yang, Yi Jiang, Xiaobo Zhou, Li K
PFM generates 3D molecules that bind to protein targets with competitive structures and SOTA binding affinities, while significantly accelerating the generation process.
bioRxiv · Jul 17, 2026 · PreprintBioinformatics