Author

Christopher Florian Holte

UiT The Arctic University of NorwayORCID 0000-0002-8156-9797Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Karolina SzafranskaiD· 3 shared Eike C. Struck· 2 shared Larissa D. KruseiD· 2 shared Peter McCourtiD· 2 shared Bartłomiej ZapotocznyiD· 1 shared Basema Abujayyab· 1 shared Dina Spigseth Hovland· 1 shared Dmitri Svistounov· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

Karolina SzafranskaORCID

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Author profile →

3 papers

Recent·Most cited

Long-term 2D monoculture of primary mouse LSEC preserves scavenging capacity and enables siRNA knockdown of Mrc1

Karolina Szafranska, Basema Abujayyab, Eike C. Struck, Dina Spigseth Hovland, Christopher Florian Holte, Gianina Dumitriu, Karen Kristine Sørensen, Peter McCourt

This study develops a 2D monoculture method to maintain primary mouse LSEC viability and endocytic function for 10 days, enabling siRNA knockdown of Mrc1.

bioRxiv · May 7, 2026 · PreprintCell Biology

Hydrogen peroxide damage to scavenging function and ultrastructure of liver sinusoidal endothelial cells is prevented by n-acetyl-cysteine but not GSH

Larissa D. Kruse, Christopher Florian Holte, Bartłomiej Zapotoczny, Eike C. Struck, Jasmin Schürstedt, Wolfgang Hübner, Thomas R. Huser, Karolina Szafranska

This study shows that hydrogen peroxide damages liver sinusoidal endothelial cells, reducing their scavenging function and causing structural changes, which can be mitigated by N-acetyl-cysteine but not glutathione.

Hepatology Communications · Jan 15, 2025Peer-reviewedCell Biology

Highly oxidized albumin is mainly cleared by mouse liver sinusoidal endothelial cells via the receptors stabilin-1 and -2

Christopher Florian Holte, Karolina Szafranska, Larissa D. Kruse, Jaione Simón-Santamaría, Ruomei Li, Dmitri Svistounov, Peter McCourt

bioRxiv · Jul 20, 2023 · PreprintMolecular Biology