Douglas S. Auld

The paper identifies two small molecules that lower PrP levels in cultured cells but show limited activity in human cell lines and in vivo.

The paper introduces a scalable platform for screening combinatorial small-molecule libraries in droplets, demonstrating its effectiveness in discovering chemical inducers of proximity and supporting machine learning-based drug design.

The paper describes the assembly of a chemogenetic library through data mining and crowdsourcing, sharing 4186 compounds with annotated gene targets.