Systematic Chemogenetic Library Assembly
Stephen M. CanhamiD, Yuan WangiD, Allen Cornett, Douglas S. AuldiD, Daniel K. BaeschliniD, Maude Patoor, Philip R. Skaanderup, Ayako HondaiD, Luis Llamas, Greg Wendel, Felipa MapaiD, Peter AspesiiD, Nancy Labbé-GiguèreiD, Gabriel G. Gamber, Daniel S. PalaciosiD, Ansgar SchuffenhaueriD, Zhan DengiD, Florian NigschiD, Mathias Ugelstad FrederikseniD, Simon M. BushelliD, Deborah M. RothmaniD, Rishi K. JainiD, Horst Hemmerle, Karin Briner, Jeffery A. Porter, , Jeremy L. JenkinsiD
Abstract
The assembly of chemogenetic libraries composed of chemical probes provides tremendous value to biomedical research, but requires substantial effort to ensure diversity as well as quality of the contents. We are assembling a chemogenetic library by data mining and crowdsourcing institutional expertise. We are sharing our methodology, lessons learned, and disclosing our current collection of 4186 compounds with their primary annotated gene targets.
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