H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
Yichao Cai, Ying Zhang, Yan Ping Loh, Jia Qi Tng, Mei Chee Lim, Zhendong Cao, Anandhkumar Raju, Erez Lieberman Aiden, Shang Li, Manikandan Lakshmanan, Vinay Tergaonkar, Greg Tucker‐Kellogg, Melissa J. Fullwood
The paper identifies H3K27me3-rich regions as silencers that repress gene expression through chromatin interactions and shows their functional impact on cell identity and tumor growth.
Nature Communications · Jan 29, 2021Peer-reviewedGenomics