Protein scaffold-based multimerization of soluble ACE2 efficiently blocks SARS-CoV-2 infection in vitro and in vivo
Alişan Kayabölen, Uğur Akcan, Doğancan Özturan, Hivda Ülbeği Polat, Gizem Nur Şahin, Nareg Pinarbasi Degirmenci, Canan Bayraktar, Gizem Söyler, Ehsan Sarayloo, Elif Nurtop, Berna Özer, Gülen Güney-Esken, Tayfun Barlas, Ismail Selim Yildirim, Özlem Doğan, , Tugba Bagci Onder
The paper develops multimeric sACE2 decoys using SunTag or MoonTag systems, showing >100-fold increased SARS-CoV-2 neutralization compared to monomeric sACE2.
Advanced Science · Jul 27, 2022Peer-reviewedMolecular Biology