Alişan Kayabölen

DDRKOL identifies essential DDR genes in glioblastoma using CRISPR screens, revealing four high-confidence candidates validated across multiple assays and models.

This paper develops strategies to redirect lipid nanoparticle targeting away from the liver and toward specific tissues using engineered proteins and antibody conjugation.

This paper introduces EVOLVEpro, a few-shot learning framework using protein language models to rapidly improve protein activity with minimal experimental data.

This paper introduces PRECISE, a method for programmable RNA editing that enables precise insertion, substitution, and deletion of RNA sequences in pre-mRNAs, with high efficiency and fidelity.

The paper identifies widespread RNA-guided nucleases in eukaryotes and their viruses, showing they can be used for genome editing in human cells.

The paper develops multimeric sACE2 decoys using SunTag or MoonTag systems, showing >100-fold increased SARS-CoV-2 neutralization compared to monomeric sACE2.