Author

Takeshi Hiramoto

The University of Texas at San Antonio Health Science CenterORCID 0000-0002-8205-5579Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Gina KangiD· 5 shared Noboru HiroiiD· 5 shared Takahira YamauchiiD· 4 shared Kenji TanigakiiD· 3 shared Takefumi KikusuiiD· 3 shared Akihiro Machida· 2 shared Akira SumiyoshiiD· 2 shared Hiroi Nonaka· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersNeuroscience

Gina KangORCID

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Author profile →

5 papers

Recent·Most cited

Neonatal social communication and single genes predict the variability of post-pubertal social behavior in a mouse model of paternal 15q11-13 duplication

Takahira Yamauchi, Kota Tamada, Takeshi Takano, Mitsuteru Nakamura, Mariel Barbachan E. Silva, Kenny Q. Ye, Hitoshi Inada, Takaki Tanifuji, Takeshi Hiramoto, Lucas J. Stevens, Gina Kang, Marisa Zamora Esparza, Takefumi Kikusui, Noriko Osumi, Pilib Ó Broin, , Noboru Hiroi

The paper predicts post-pubertal social behavior variability in a mouse model of paternal 15q11-13 duplication using neonatal social communication and gene expression data.

bioRxiv · Jan 18, 2026 · PreprintNeuroscience

Structural alterations in the amygdala and impaired social incentive learning in a mouse model of a genetic variant associated with neurodevelopmental disorders

Takeshi Hiramoto, Akira Sumiyoshi, Risa Kato, Takahira Yamauchi, Gina Kang, Bailey Matsumura, Lucas J. Stevens, Rie Ryoke, Hiroi Nonaka, Akihiro Machida, Kensaku Nomoto, Kazutaka Mogi, Yukiko J. Hiroi, Takefumi Kikusui, Ryuta Kawashima, Noboru Hiroi

This study examines structural brain changes and social behavior in Tbx1 heterozygous mice, linking reduced amygdala volume to impaired social incentive learning.

bioRxiv · Jun 14, 2023 · PreprintNeuroscience

Transcriptional regulation of neonatal neural stem cells is a determinant of social behavior

Takeshi Hiramoto, Shuken Boku, Gina Kang, Seiji Abe, Mariel Barbachan e Silva, Kenji Tanigaki, Masako Nagashima, Kenny Q. Ye, Takahira Yamauchi, Tatyana V. Michurina, Pilib Ó Broin, Grigori Enikolopov, Noboru Hiroi

The paper investigates how Tbx1 deficiency in neonatal neural stem cells affects social behavior and identifies its role in neurodevelopmental disorders.

bioRxiv · Nov 12, 2021 · PreprintNeuroscience

Tbx1, a 22q11.2-encoded gene, is a link between alterations in fimbria myelination and cognitive speed in mice

Takeshi Hiramoto, Akira Sumiyoshi, Takahira Yamauchi, Kenji Tanigaki, Qian Shi, Gina Kang, Rie Ryoke, Hiroi Nonaka, Shingo Enomoto, Takeshi Izumi, Manzoor A. Bhat, Ryuta Kawashima, Noboru Hiroi

This study shows that Tbx1 deletion in mice affects myelination and cognitive speed, linking 22q11.2 CNV alterations to cognitive deficits.

Molecular Psychiatry · Nov 4, 2021Peer-reviewedNeuroscience

Maternal approach behaviors toward neonatal calls are impaired by mother's experiences of raising pups with a risk gene variant for autism

Risa Kato, Akihiro Machida, Kensaku Nomoto, Gina Kang, Takeshi Hiramoto, Kenji Tanigaki, Kazutaka Mogi, Noboru Hiroi, Takefumi Kikusui

The paper shows that maternal approach behaviors toward neonatal mouse calls are influenced by the mother's prior experience with pups carrying a risk gene variant for autism.

Developmental Psychobiology · Jun 23, 2020Peer-reviewedDevelopmental Biology