Kenny Q. Ye

Benchmarking Twist Genotyping-by-Sequencing Against Whole-Genome Sequencing in Nuclear Families

This study benchmarks Twist Genotyping-by-Sequencing against whole-genome sequencing in nuclear families, finding GxS slightly worse than GSA but still highly concordant with WGS.

Neonatal social communication and single genes predict the variability of post-pubertal social behavior in a mouse model of paternal 15q11-13 duplication

The paper predicts post-pubertal social behavior variability in a mouse model of paternal 15q11-13 duplication using neonatal social communication and gene expression data.

Acetylation of histone H2B on lysine 120 regulates BRD4 binding to intergenic enhancers

The paper identifies H2BK120ac as critical for BRD4 recruitment to intergenic enhancers and shows its role in BRD4-NUT-driven oncogenesis.

Transcriptional regulation of neonatal neural stem cells is a determinant of social behavior

The paper investigates how Tbx1 deficiency in neonatal neural stem cells affects social behavior and identifies its role in neurodevelopmental disorders.

Spatial organization of transcript elongation and splicing kinetics

This study measures Pol II elongation and splicing kinetics genome-wide and finds they are coordinated by spatial genomic organization, particularly within TADs.

Mosaic Chromosomal Aneuploidy Detection By Sequencing (MAD-seq)

MAD-seq detects low-level mosaic chromosomal aneuploidy using a new sequencing assay and analysis method, revealing previously unrecognized aneuploidy in public datasets.