Enabling non-viral DNA delivery using lipid nanoparticles co-loaded with endogenous anti-inflammatory lipids
Manthan N. Patel, Sachchidanand Tiwari, Yufei Wang, Sarah O’Neill, Jichuan Wu, Serena Omo‐Lamai, Carolann L. Espy, Liam S. Chase, Aparajeeta Majumder, Evan T. Hoffman, Anit Shah, András Sárközy, Jeremy B. Katzen, Norbert Pardi, Jacob Samuel Brenner
This study develops lipid nanoparticles co-loaded with anti-inflammatory lipids to reduce inflammation from DNA delivery, enabling prolonged transgene expression.
Nature Biotechnology · Feb 5, 2025Peer-reviewedBioengineering