Sachchidanand Tiwari

This study develops a tetravalent dengue mRNA vaccine that induces broad, durable, and protective immunity across all four serotypes in mice.

This study shows that targeting DNA-LNPs to endothelial cells enhances transgene expression magnitude, duration, and specificity in target organs.

This study shows that inhibiting endothelial AGO1 reduces vascular inflammation and atherosclerosis by blocking its non-canonical nuclear role in promoting NF-κB-driven inflammation.

This study develops lipid nanoparticles co-loaded with anti-inflammatory lipids to reduce inflammation from DNA delivery, enabling prolonged transgene expression.

This paper introduces multi-stage-mixing (MSM) to control lipid nanoparticle (LNP) supramolecular structure, creating a core-then-shell arrangement that significantly improves mRNA and DNA-LNP performance.

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.