Norbert Pardi

This study develops a tetravalent dengue mRNA vaccine that induces broad, durable, and protective immunity across all four serotypes in mice.

This study identifies a dual-antigen CCHFV vaccine candidate that induces neutralizing immunity and protects against lethal viral challenge.

This study investigates how booster immunizations affect germinal center (GC) clonality in mice, finding that refueling leads to clonal expansion rather than memory recruitment.

The paper presents two assays for analyzing influenza mRNA vaccines: a DNA microarray for mRNA identity and quantity, and a multiplexed immunoassay for protein expression.

This study develops a lymphatic endothelial cell-targeting lipid nanoparticle for mRNA delivery, improving lymphatic function after injury.

This paper develops an mRNA-launched nanoparticle vaccine that combines protein nanoparticle and mRNA vaccine advantages, showing enhanced antibody and T cell responses in mice.

Stabilizing H5 HA mutations enhance neutralizing antibody responses by shifting epitope targeting toward the receptor binding site in vaccinated mice.

This study shows mRNA-LNP vaccines against HBV induce strong immune responses in both preventive and chronic infection models in mice.

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

This paper demonstrates transient prime editor expression in mice to correct a genetic liver disease, reducing blood phenylalanine levels below the therapeutic threshold.

This study shows that inhibiting endothelial AGO1 reduces vascular inflammation and atherosclerosis by blocking its non-canonical nuclear role in promoting NF-κB-driven inflammation.

This study shows that endogenous antigen processing via MHC II is critical for mRNA-LNP vaccine-induced CD4+ T cell responses, challenging the traditional view of exogenous antigen processing.

This paper shows that temporarily blocking type I interferon during viral infection boosts CD8+ T cell memory and vaccine effectiveness by promoting TSCM cell formation.

This study develops lipid nanoparticles co-loaded with anti-inflammatory lipids to reduce inflammation from DNA delivery, enabling prolonged transgene expression.

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

The paper demonstrates that transient mRNA-based growth factor expression in lipid nanoparticles enhances PHH engraftment and liver function in murine liver disease models.

This study identifies distinct roles of nucleoside-modified mRNA and lipid nanoparticles in promoting Tfh cell responses through different mechanisms.