Author

Yufei Wang

University of PennsylvaniaORCID 0000-0002-9719-0773Unclaimed ORCID profile · follow to get notified of new preprints

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Yufei Wang2 papers · School of Electronics and Information, Northwestern Polytechnical University, Xi'an, 710072, China;

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:DNA methylation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Anit ShahiD· 2 shared Aparajeeta MajumderiD· 2 shared Carolann L. EspyiD· 2 shared Jacob Samuel BrenneriD· 2 shared Jeremy B. KatzeniD· 2 shared Liam S. ChaseiD· 2 shared Manthan N. PateliD· 2 shared Serena Omo‐LamaiiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersBioengineering

Anit ShahORCID

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2 papers

Recent·Most cited

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects

Serena Omo‐Lamai, Yufei Wang, Manthan N. Patel, Aleksa Milosavljevic, Daniel W. Zuschlag, Subhajit Poddar, Jichuan Wu, Liuqian Wang, Fengyi Dong, Carolann L. Espy, Aparajeeta Majumder, Eno‐Obong Essien, Mengwen Shen, Breana Channer, Tyler Ellis Papp, , Jacob Samuel Brenner

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

Nature Nanotechnology · Aug 11, 2025Peer-reviewedBioengineering

Enabling non-viral DNA delivery using lipid nanoparticles co-loaded with endogenous anti-inflammatory lipids

Manthan N. Patel, Sachchidanand Tiwari, Yufei Wang, Sarah O’Neill, Jichuan Wu, Serena Omo‐Lamai, Carolann L. Espy, Liam S. Chase, Aparajeeta Majumder, Evan T. Hoffman, Anit Shah, András Sárközy, Jeremy B. Katzen, Norbert Pardi, Jacob Samuel Brenner

This study develops lipid nanoparticles co-loaded with anti-inflammatory lipids to reduce inflammation from DNA delivery, enabling prolonged transgene expression.

Nature Biotechnology · Feb 5, 2025Peer-reviewedBioengineering