Liangcai Gu

Linker-Length Landscape Mapping Enables Coupling of Diverse Synthetic Chemically Induced Dimerization Systems to Molecular Readouts

The paper introduces a method to map linker-length landscapes for coupling synthetic CID systems to molecular readouts, showing linker length strongly affects coupling efficiency.

Single-cell and spatial detection of senescent cells using DeepScence

DeepScence identifies senescent cells in single-cell and spatial transcriptomics data, outperforming existing methods.

A diverse population of pericoerulear neurons controls arousal and exploratory behaviors

The paper identifies diverse GABAergic neurons in the locus coeruleus (LC) dendritic field that modulate arousal and behaviors through transcriptional, spatial, and functional diversity.

Continuous Polony Gels for Tissue Mapping with High Resolution and RNA Capture Efficiency

PIXEL-seq barcodes tissue sections with continuous polony clusters on a gel surface, reporting ≤1 µm resolution and >1,000 unique molecular identifiers per 10x10 µm2.

Creating Red Light-Controlled Protein Dimerization Systems as Genetically Encoded Actuators with High Specificity

The paper introduces a method to create red light-controlled protein dimerization systems with high specificity for optogenetic applications.