Author

Runze Dong

University of WashingtonORCID 0000-0002-7294-3070Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Pathology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Liangcai GuiD· 3 shared Xiaonan Fu· 2 shared Andrew B. NixoniD· 1 shared Bing JiiD· 1 shared Carolyn GlassiD· 1 shared Cliburn C. W. ChaniD· 1 shared Congkuo DuiD· 1 shared David Vaisar· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBioinformatics

Liangcai GuORCID

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Author profile →

4 papers

Recent·Most cited

VGLL4 promotes thoracic aortic aneurysm and dissection by disrupting extracellular matrix homeostasis via WISP1-mediated TIMP3/MMP9 imbalance

Lu Ding, Jianshe Ma, Pinmeng Diao, Runze Dong, Yutao Tong, Jinbiao Lai, Yuyue Shao, Minjie Hu, Jiwen Yang, Peifeng Jin, Xiaofang Fan, Yongsheng Gong, Congkuo Du, Xuejiao Chen, Xiufang Chen, , Yongyu Wang

This study identifies VGLL4 as a mechanosensitive regulator of TAAD by disrupting ECM homeostasis through the WISP1-TIMP3/MMP9 axis.

bioRxiv · Aug 30, 2026 · PreprintPathology

Single-cell and spatial detection of senescent cells using DeepScence

Yilong Qu, Bing Ji, Runze Dong, Liangcai Gu, Cliburn C. W. Chan, Jichun Xie, Carolyn Glass, Xiao‐Fan Wang, Andrew B. Nixon, Zhicheng Ji

DeepScence identifies senescent cells in single-cell and spatial transcriptomics data, outperforming existing methods.

Cell Genomics · Oct 7, 2025Peer-reviewedBioinformatics

Continuous Polony Gels for Tissue Mapping with High Resolution and RNA Capture Efficiency

Xiaonan Fu, Li Jun Sun, Jane Chen, Runze Dong, Yiing Lin, Richard D. Palmiter, Shin Lin, Liangcai Gu

PIXEL-seq barcodes tissue sections with continuous polony clusters on a gel surface, reporting ≤1 µm resolution and >1,000 unique molecular identifiers per 10x10 µm2.

bioRxiv · Mar 17, 2021 · PreprintGenomics

Creating Red Light-Controlled Protein Dimerization Systems as Genetically Encoded Actuators with High Specificity

Zhimin Huang, Zengpeng Li, Xiao Zhang, Runze Dong, Shoukai Kang, Li Sun, Xiaonan Fu, David Vaisar, Kurumi Watanabe, Liangcai Gu

The paper introduces a method to create red light-controlled protein dimerization systems with high specificity for optogenetic applications.

bioRxiv · Jul 9, 2020 · PreprintSynthetic Biology