Microglia-targeted dendrimer-2PMPA therapy robustly inhibits GCPII and improves cognition in a mouse model of multiple sclerosis
Kristen R. Hollinger, Anjali Sharma, Carolyn Tallon, Lyndah E. Lovell, Ajit G. Thomas, Xiaolei Zhu, Siva P. Kambhampati, Kevin Liaw, Rishi B. Sharma, Camilo J. Rojas, Rana Rais, Sujatha Kannan, Rangaramanujam M. Kannan, Barbara Stauch Slusher
This paper develops a dendrimer-conjugated GCPII inhibitor (D-2PMPA) that improves cognition in MS mice without affecting disease severity.
bioRxiv · Apr 22, 2020 · PreprintNeuroscience