Xiaolei Zhu

This study introduces an ultra-rare AKAP11 protein-truncating variant in mice, showing it causes anxiety- and depression-like behaviors and disrupts PKA signaling.

This study shows that adolescent THC exposure causes microglial apoptosis in the mPFC, which is worsened by 16p11.2 duplication, leading to social memory deficits via microglial Cnr1.

This paper develops a dendrimer-conjugated GCPII inhibitor (D-2PMPA) that improves cognition in MS mice without affecting disease severity.