Rangaramanujam M. Kannan

This paper identifies an AKT1-TERT-FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE cells under stress.

This study identifies a diet-induced metabolic-immune axis linking gut microbiome changes to systemic immune aging and retinal degeneration in mice and AMD patients.

This study evaluates dendrimer-radioconjugates with Actinium-225 and low-dose cisplatin for treating metastatic triple negative breast cancer across different anatomical sites in mice, showing improved survival without long-term toxicity.

This study shows that systemic actinium-225 dendrimer-radioconjugates improve glioblastoma survival in mice, with enhanced efficacy when combined with temozolomide.

The paper develops OcuPair, a hydrogel bandage for corneal injuries that seals wounds and maintains eye stability, showing effectiveness in ex vivo and animal models.

This study shows that dendrimer-targeted immunosuppression of microglia accelerates photoreceptor regeneration in zebrafish retinas.

This paper develops a dendrimer-conjugated GCPII inhibitor (D-2PMPA) that improves cognition in MS mice without affecting disease severity.