The Endo-GeneScreen Platform Identifies Drug-Like Probes that Regulate Endogenous Protein Levels within Physiological Contexts
Preston N. Samowitz, László Radnai, Thomas Vaissière…·Gavin Rumbaugh
The paper introduces Endo-GeneScreen, a platform that identifies small molecules regulating endogenous protein levels, and demonstrates its application in finding probes for Syngap1-related neurodevelopmental disorder.