Lucía Chávez‐Gutiérrez

Unbiased data-driven analysis of five amyloid-beta peptides for biomarker investigations in familial Alzheimer's disease

The paper uses data-driven analysis of amyloid-beta peptides to identify biomarkers for familial Alzheimer's disease and predict age-at-onset in PSEN1 mutation carriers.

Spectrum of gamma-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes

The paper examines the relationship between Aβ peptide profiles and age at symptom onset in ADAD, finding linear correlations that support a unified model of pathogenesis.

Functional and topological analysis of PSENEN, the fourth subunit of the gamma-secretase complex

This study investigates the role of PSENEN in the gamma-secretase complex, showing its structural and functional importance in complex formation and cleavage activity.

Plasma amyloid beta ratios in autosomal dominant Alzheimers disease: the influence of genotype

The paper analyzes plasma A{beta} ratios in ADAD mutation carriers and non-carriers, finding significant differences between PSEN1 and APP carriers and associations with parental age at onset.