Author

Sara Gutiérrez Fernández

VIB-KU Leuven Center for Brain & Disease ResearchORCID 0000-0002-7479-0768Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Lucía Chávez‐GutiérreziD· 2 shared Charlien VandersmisseniD· 1 shared Cristina Gan Oria· 1 shared Dieter PetitiD· 1 shared Heidi SegersiD· 1 shared Jan CoolsiD· 1 shared John Matthew RingmaniD· 1 shared Kris JacobsiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Lucía Chávez‐GutiérrezORCID

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2 papers

Recent·Most cited

Spectrum of gamma-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes

Sara Gutiérrez Fernández, Cristina Gan Oria, Dieter Petit, Wim G. Annaert, John Matthew Ringman, Nick C. Fox, Natalie Sarah Ryan, Lucía Chávez‐Gutiérrez

The paper examines the relationship between Aβ peptide profiles and age at symptom onset in ADAD, finding linear correlations that support a unified model of pathogenesis.

Molecular Neurodegeneration · Apr 25, 2025Peer-reviewedNeuroscience

Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

Charlien Vandersmissen, Sofie Demeyer, Kris Jacobs, Lien Boogaerts, Sara Gutiérrez Fernández, Heidi Segers, Lucía Chávez‐Gutiérrez, Jan Cools

The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.

bioRxiv · Mar 1, 2024 · PreprintCancer Biology