This study identifies that plasma proteins selectively reflect tissue-specific aging processes in muscle and ovary, revealing context-dependent age-related changes.

bioRxiv · Oct 24, 2026 · PreprintSystems Biology

Manifestations of genetic risk for Alzheimer's Disease in the blood: a cross-sectional multi-omic analysis in healthy adults aged 18-90+

Laura M. Heath, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, Benjamin A. Logsdon, Lara M. Mangravite, Brian W. Kunkle, Eden R. Martin, Adam Christian Naj, Nilüfer Ertekin‐Taner, Todd Eliot Golde, Leroy Hood, , Jeffrey Alan Kaye

This study identifies blood-based biomarkers associated with Alzheimer's disease genetic risk variants in a large cohort of healthy adults, showing effects from early adulthood and sex-specific patterns.

Scientific Reports · Apr 12, 2022Peer-reviewedGenetics

Gut Microbiome Pattern Reflects Healthy Aging and Predicts Extended Survival in Humans

Tomasz Maciej Wilmanski, Christian Diener, Noa Rappaport, Sushmita Patwardhan, Jack T. Wiedrick, Jodi Lapidus, John C. Earls, Anat Zimmer, Gustavo Glusman, Max Robinson, James T. Yurkovich, Deborah M. Kado, Jane A. Cauley, Joseph M. Zmuda, Nancy E. Lane, , Nathan D. Price

The paper shows that gut microbiome uniqueness increases with age and predicts survival in humans.

Nature Metabolism · Feb 18, 2021Peer-reviewedBioinformatics

Blood metabolome signature predicts gut microbiome α-diversity in health and disease

Tomasz Maciej Wilmanski, Noa Rappaport, John C. Earls, Andrew T. Magis, Ohad Manor, Jennifer C. Lovejoy, Gilbert S. Omenn, Leroy Hood, Sean M. Gibbons, Nathan D. Price

The paper identifies a blood metabolome signature that robustly predicts gut microbiome α-diversity across health and disease conditions.

Nature Biotechnology · Sep 2, 2019Peer-reviewedBioinformatics