Nancy E. Lane

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA)

The paper examines the association between skeletal muscle gene expression and knee osteoarthritis in older adults using bulk RNA sequencing from the SOMMA study.

MicroRNA regulatory targets of VO2peak in older adult participants of the Study of Muscle Mobility and Aging (SOMMA)

The paper identifies miRNA-gene regulatory networks associated with VO2peak in older adults using RNA sequencing and pathway analysis.

Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis

This study identifies Basigin's role in GC-induced bone loss and impaired angiogenesis by linking altered skeletal stem cell dynamics to vascular dysfunction, showing that anti-Basigin therapy can reverse these effects.

MicroRNA signatures of VO2peak in older adult participants of the Study of Muscle, Mobility and Aging

The paper identifies miRNA signatures associated with VO2peak variation in older adults using serum small RNA sequencing and statistical analysis.

Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females

This paper identifies CCN3 as a brain-derived hormone that promotes bone mass in lactating females by compensating for estrogen loss and supporting skeletal stem cells.

Hip joint space width is causally related to hip osteoarthritis risk via distinct protective and susceptibility mechanisms: findings from a genome-wide association study meta-analysis

This study identifies genetic determinants of hip joint space width and finds they have opposing causal effects on hip osteoarthritis risk through distinct mechanisms.

Plant-based Production and Characterization of a Promising Fc-fusion Protein against Bone Mass Density Loss

This study produces and characterizes a plant-based PTH-Fc fusion protein that shows similar potency to PTH (1-34) in binding and activating PTH1R, making it suitable for space medicine applications.

Gut Microbiome Pattern Reflects Healthy Aging and Predicts Extended Survival in Humans

The paper shows that gut microbiome uniqueness increases with age and predicts survival in humans.

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

This paper conducts a genome-wide meta-analysis of chronic back pain in 158,025 individuals, identifying three genetic loci associated with the condition.