Mary Ellen Pavone

Matched Plasma and Tissue Proteomics Reveal the Selective Nature of Circulating Biomarkers of Human Aging

This study identifies that plasma proteins selectively reflect tissue-specific aging processes in muscle and ovary, revealing context-dependent age-related changes.

The human ovary exhibits dynamic molecular remodeling in the decades post-menopause

This study identifies age-related molecular changes in postmenopausal ovaries using proteomics, revealing dynamic remodeling and new biological insights.

Proteogenomic Profiling Reveals a Distinct Endogenous p16INK4a-Associated Senescence Signature in the Human Ovary.

The paper identifies a distinct p16INK4a-associated senescence signature in human ovarian tissue through proteogenomic profiling and spatial analysis.

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics

The paper identifies and maps senescent cells in postmenopausal ovaries using p16 expression and spatial transcriptomics, revealing a fibro-inflammatory signature associated with aging.

A comprehensive multi-omics signature of doxorubicin-induced cellular senescence in the postmenopausal human ovary.

The paper establishes a senotype of doxorubicin-induced senescence in postmenopausal human ovarian tissue using single nuclei sequencing and proteomics.