Rémy Sadoul

Dimeric Alix nucleates ESCRT-III CHMP4 polymerization

This study shows dimeric Alix nucleates CHMP4 polymerization, essential for ESCRT-III membrane remodeling, and demonstrates that dimerization is required for plasma membrane repair.

Lack of evidence for cargo release of CD63-EVs into recipient cells

This study shows that CD63-exosomes do not fuse with recipient cell membranes to release their cargo, challenging the common belief that exosomes deliver molecular cargo via membrane fusion.

CARM1-mediated methylation controls interactions of ALIX with key partners important for cytokinesis

This study identifies CARM1-mediated methylation of ALIX as critical for its interactions with SH3-domain proteins during cytokinesis.

ALG-2 interacting protein-X (Alix) is required for activity-dependent bulk endocytosis at brain synapses

This study shows that Alix is required for activity-dependent bulk endocytosis at brain synapses, and its absence reduces seizure severity in mice.