The paper integrates positive selection signatures with genetic data to identify metabolically relevant loci in South Asians, finding the MAPT locus associated with insulin resistance.

medRxiv · Jun 22, 2026 · PreprintGenetic & Genomic Medicine

Parental haplotypes reconstruction in up to 440,209 individuals reveals recent assortative mating dynamics

Robin J. Hofmeister, Davide Marnetto, Théo Cavinato, Leona Knüsel, Giorgia Modenini, Erwan Pennarun, Nicola Barban, Reedik Mägi, Tabea Schoeler, Luca Pagani, Zoltán Kutalik

The paper estimates genetic assortative mating using haplotype reconstruction in large biobank cohorts, revealing recent trends in mate choice and its genetic impact.

bioRxiv · Sep 24, 2025 · PreprintGenetics

An ancestry-enriched HNF4A variant and GP2 reveal distinct mechanisms of type 2 diabetes in exome-wide study of 13,674 cases and 41,024 controls

Sam Hodgson, Vi Bui, Siqi Hu, Cyrielle Maroteau, Margherita Bigossi, Alicia Huerta-Chagoya, Trang Nguyen, Adem Y. Dawed, Ryan Koesterer, Maheak Vora, Daniel Stow, Alice Williamson, Alexandra M. Blee, Julia Carrasco-Zanini Sanchez, Viswanathan Baskar, , Moneeza Kalhan Siddiqui

The paper identifies ancestry-specific T2D risk variants in South Asian populations through exome-wide association study and functional validation.

medRxiv · Sep 24, 2025 · PreprintGenetic & Genomic Medicine

Genome-wide analysis of Corsican population reveals a close affinity with Northern and Central Italy

Erika Tamm, Julie Di Cristofaro, Stéphane Mazières, Erwan Pennarun, Alena Kushniarevich, Alessandro Raveane, Ornella Semino, Jacques Chiaroni, Luı́sa Pereira, Mait Metspalu, Francesco Montinaro

The paper analyzes genome-wide data from Corsicans and finds they are genetically closer to Northern and Central Italians than to Sardinians.

Scientific Reports · Sep 19, 2019Peer-reviewedGenomics