Moneeza Kalhan Siddiqui

The paper integrates positive selection signatures with genetic data to identify metabolically relevant loci in South Asians, finding the MAPT locus associated with insulin resistance.

The paper performs whole exome sequencing on 44,028 British South Asians to identify gene-phenotype associations and knockout genes, finding novel links and implications for drug development.

This study assesses the association between APOE genetic variants and dementia risk in British South Asians using healthcare records and genotyping data.

The paper identifies ancestry-specific T2D risk variants in South Asian populations through exome-wide association study and functional validation.

This paper examines how polygenic risk scores for adiposity relate to early type 2 diabetes onset in South Asians and Europeans, finding that BMI mediates this relationship more fully in Europeans than in South Asians.

This study estimates that ~6% of insulin-treated diabetic individuals with ambiguous features in British Pakistanis and Bangladeshis have T1D, highlighting the need for autoantibody and C-peptide testing.

This paper conducts a multi-ancestry GWAS to identify genetic loci influencing NLR and develops a PRS to assess its causal association with DR, finding no significant causal link.

This study identifies genetic loci associated with age at diagnosis of T2D in South Indian and European populations, revealing shared and distinct genetic architectures.

This study identifies XBP1 expression in pancreatic islets as a genetic factor associated with poor glycaemic control and increased T2DM risk in South and East Asians, particularly in young non-obese onset diabetes.

This study shows that considering both loss-of-function and gain-of-function variants in SLCO1B1 improves the prediction of statin intolerance compared to using only the Val174Ala variant.