Suthesh Sivapalaratnam

This study shows that VWF deficiency increases Angpt-2 expression via the Tie2-Akt-FOXO1 pathway, leading to vascular defects in the gut and suggesting Angpt-2 inhibitors could treat VWD-related bleeding.

This paper identifies 32 genes with altered expression in platelets from MPN patients, linking them to thrombosis and bleeding risks, and suggests clinical applications for risk stratification and treatment tailoring.

This study identifies 15 common and 9 low-frequency protein-coding variants associated with body fat distribution, implicating novel genes related to lipid homeostasis and type 2 diabetes.

The paper reports a diagnostic HTS test for bleeding, thrombotic, and platelet disorders, identifying molecular diagnoses in 897 out of 2,390 patients.