The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage.
Georgios Efthymiou, Coralie Compare, Eugénie Lohmann, Paraskevi Kousteridou, Pierre Marie Bertrand, Heather S. Carr, Issam Ben‐Sahra, Ivan Nemazanyy, Sarah-Simha Tubiana, Zainab Hussain, Pascal Finetti, François Bertucci, Ghislain Bidaut, Christophe Lachaud, Fabienne Guillaumond, , Sophie Vasseur
This study shows that the extracellular matrix promotes guanylate production in pancreatic cancer cells, reducing oxaliplatin-induced DNA damage and enhancing proliferation.
Science Advances · Dec 12, 2025Peer-reviewedCancer Biology