Christophe Lachaud

This study shows TERT promotes liver tumors independently of telomere elongation, revealing molecular and metabolic features relevant to immunotherapy response.

The paper introduces a 19-marker spectral flow cytometry panel to simultaneously identify hematopoietic stem, progenitor, and mature cell lineages in mouse bone marrow.

This study shows that TERT expression in adipose tissue reduces inflammation and improves metabolism in obesity by altering macrophage states and stem cell-macrophage communication.

This study shows that the extracellular matrix promotes guanylate production in pancreatic cancer cells, reducing oxaliplatin-induced DNA damage and enhancing proliferation.

This study shows that TERT reduces obesity-induced metabolic disorders by promoting adipose stem cell expansion and differentiation, and remodeling macrophages in adipose tissue.

The paper identifies UFMylation of MRE11 as critical for telomere length and hematopoietic stem cell survival, showing its role in telomere maintenance without affecting DNA repair.