Co-translational O-glycosylation driven by GALNTs spatial reprogramming fosters pancreatic cancer growth
Rebecca Bennion, Eugénie Lohmann, Giacomo Del Rio, Lucile Rouyer, Sahar El Amrani, Małgorzata Kowalczewska, Xavier Le Guezennec, Eric Mas, Nelson Dusetti, Alex Chauvin, Richard Tomasini, Sophie Vasseur, Fabienne Guillaumond, Brice Chanez, Martin James Humphries, , Frédéric Bard
The paper shows that GALA, a process relocating GALNTs to the ER, enables co-translational O-glycosylation in pancreatic cancer, expanding the O-glycoproteome and promoting tumor growth.
bioRxiv · Sep 8, 2026 · PreprintCancer Biology