Author

Heather S. Carr

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Issam Ben‐SahraiD· 2 shared Austin T. Klein· 1 shared Christophe LachaudiD· 1 shared Coralie Compare· 1 shared Daniel James McGrailiD· 1 shared Eugénie Lohmann· 1 shared Fabienne GuillaumondiD· 1 shared François BertucciiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Issam Ben‐SahraORCID

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2 papers

Recent·Most cited

The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage.

Georgios Efthymiou, Coralie Compare, Eugénie Lohmann, Paraskevi Kousteridou, Pierre Marie Bertrand, Heather S. Carr, Issam Ben‐Sahra, Ivan Nemazanyy, Sarah-Simha Tubiana, Zainab Hussain, Pascal Finetti, François Bertucci, Ghislain Bidaut, Christophe Lachaud, Fabienne Guillaumond, , Sophie Vasseur

This study shows that the extracellular matrix promotes guanylate production in pancreatic cancer cells, reducing oxaliplatin-induced DNA damage and enhancing proliferation.

Science Advances · Dec 12, 2025Peer-reviewedCancer Biology

Succinate dehydrogenase activity supports de novo purine synthesis

Mushtaq Ahmad Nengroo, Austin T. Klein, Heather S. Carr, Olivia Vidal-Cruchez, Umakant Sahu, Daniel James McGrail, Nidhi Sahni, Niklas B. Thompson, Peter Allen Faull, Peng Gao, John M. Asara, Hardik Shah, Marc L. Mendillo, Issam Ben‐Sahra

This study shows that succinate dehydrogenase supports de novo purine synthesis in cancer cells, and its inhibition reduces proliferation by impairing purine biosynthesis and inducing a compensatory salvage pathway.

Molecular Cell · Oct 28, 2025Peer-reviewedBiochemistry