Cell BiologybioRxivPreprint
Mitochondrial damage triggers therapy-induced senescence
Chrysiida Baltira, Ferhat Alkan, Isabel Mayayo‐Peralta…·Mark C. de Gooijer
The paper shows that mitochondrial damage can induce therapy-induced senescence in GBM cells through a ROS-cGAS-STING-SASP cascade, outperforming single or dual pathway inhibitors.
DOI 10.1101/2024.12.20.629667