Author

Daria M. Fedorushkova

The Netherlands Cancer InstituteORCID 0000-0002-4217-5445Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Jos H. BeijneniD· 2 shared Laura E. KuiliD· 2 shared Mark C. de GooijeriD· 2 shared Olaf van TellingeniD· 2 shared Ana Rita R. MaiaiD· 1 shared Anna Their· 1 shared Bram ThijsseniD· 1 shared Ceren H. Çitirikkaya· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Jos H. BeijnenORCID

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2 papers

Recent·Most cited

Cancer BiologyCellular OncologyPeer-reviewedFeb 16, 2026

Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma

Mark C. de Gooijer, Daria M. Fedorushkova, Ping Zhang…·Olaf van Tellingen

This study evaluates the efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma in vitro and in vivo, finding strong in vitro activity but no antitumor effect in mouse models.

3 citationstop 4%

mouseexperimental assay

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Cell BiologybioRxivPreprintDec 20, 2024

Mitochondrial damage triggers therapy-induced senescence

Chrysiida Baltira, Ferhat Alkan, Isabel Mayayo‐Peralta…·Mark C. de Gooijer

The paper shows that mitochondrial damage can induce therapy-induced senescence in GBM cells through a ROS-cGAS-STING-SASP cascade, outperforming single or dual pathway inhibitors.

DOI 10.1101/2024.12.20.629667

humanbulk RNA-seq

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