Mitochondrial damage triggers therapy-induced senescence
Chrysiida Baltira, Ferhat Alkan, Isabel Mayayo‐Peralta, Míriam Guillén Navarro, Bram Thijssen, Rose Lempers, Kimberley Pello, Daria M. Fedorushkova, Anna Their, Fleur Jochems, Kicky Rozing, Onno B. Bleijerveld, Hans Janssen, Laura E. Kuil, Jos H. Beijnen, , Mark C. de Gooijer
The paper shows that mitochondrial damage can induce therapy-induced senescence in GBM cells through a ROS-cGAS-STING-SASP cascade, outperforming single or dual pathway inhibitors.
bioRxiv · Dec 20, 2024 · PreprintCell Biology