Yan Yun

A cohesion optimum underlies chromosome segregation fidelity in oocytes

This study shows that age-related changes in cohesion strength in oocytes lead to different types of chromosome segregation errors in eggs from young and old females.

SUMO mediates the coordinate regulation of meiotic chromosome length and crossover rate

This study shows SUMO regulates meiotic chromosome length and crossover rate in mice by affecting chromatin loop and axis organization.

Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis

The paper investigates the distinct and interdependent roles of three RING proteins in regulating meiotic recombination in mice, revealing their unique spatiotemporal dynamics and functional relationships.

Maternal Obesity Enhances Oocyte Chromosome Abnormalities Associated With Aging

This study shows maternal obesity increases chromosome abnormalities in oocytes, likely due to weakened sister-chromatid cohesion, and this effect is more pronounced in older mice.

Impeding DNA Break Repair Enables Oocyte Quality Control

This study shows RNF212 mediates oocyte quality control by impeding DNA break repair during meiosis, ensuring defective eggs are eliminated.