Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Ka Kiu Lee, Urszula Łapińska, Giulia Tolle, Maureen Micaletto, Bing Zhang, Wanida Phetsang, Anthony D. Verderosa, Brandon M. Invergo, Joseph Westley, Attila Bebes, Raif Yuecel, Paul A. O’Neill, Audrey Farbos, Aaron R. Jeffries, Stineke van Houte, , Stefano Pagliara
This study shows that subpopulations of stationary phase bacteria resist antimicrobial peptides through enhanced efflux and other mechanisms, and suggests combining tachyplesin with sertraline to combat resistance.
eLife · Sep 3, 2024Peer-reviewedMicrobiology