Stineke van Houte

This study demonstrates that mobile CRISPR-Cas9 tools can effectively prevent the dissemination of an AMR plasmid from K. pneumoniae to E. coli under various experimental conditions.

The paper shows that diversity in restriction-modification systems is maintained through trade-offs between defense strength and horizontal transferability, and provides collective protection against phages.

This study shows that loss of type I restriction-modification methyltransferases in Pseudomonas aeruginosa increases fluoroquinolone persistence through enhanced SOS response and slower growth.

The paper defines the mechanism of the MANTIS defence system in Pseudomonas aeruginosa, showing how dual ATPases couple self-modification to non-self restriction through adenine hemimethylation and cleavage.

The paper shows that removing genetic barriers from Pseudomonas aeruginosa hosts increases the diversity of recoverable phages, leading to the isolation of 69 new phages from clinical isolates.

This study shows that plasmid-borne CRISPR-Cas is beneficial in plasmid competition but is hindered by toxin-antitoxin systems in horizontally transferred plasmids.

This study investigates CRISPR-Cas9 antimicrobial activity against E. coli ST131 and identifies two escape mechanisms, showing that genetic context of the target gene influences escape frequency.

The paper investigates eco-evolutionary feedbacks between restriction-modification systems and antimicrobial resistance gene acquisition using modeling and genome analysis.

This study tracks changes in gut plasmid populations and antibiotic resistance during and after antibiotic therapy in a single patient with ESBL-carrying E. coli.

This study shows that subpopulations of stationary phase bacteria resist antimicrobial peptides through enhanced efflux and other mechanisms, and suggests combining tachyplesin with sertraline to combat resistance.