Jonathan M. Wong

Increased excitation-inhibition balance due to a loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction

The paper investigates the relationship between NMDA receptor hypofunction and GABAergic synapse loss in SRKO mice, finding reduced inhibitory synapses and increased excitation-inhibition imbalance.

Postsynaptic serine racemase regulates NMDA receptor function

This study shows that postsynaptic serine racemase regulates NMDA receptor function in mouse hippocampal neurons, with age-dependent effects on long-term potentiation and GluN2B expression.

Long-term depression is independent of GluN2 subunit composition.

This study shows that neither GluN2A nor GluN2B subunits are strictly required for non-ionotropic or ionotropic long-term depression.